Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins
September 2016
in “
British journal of dermatology/British journal of dermatology, Supplement
”
hair follicle dermal cells bioengineered skin interfollicular dermal fibroblasts hair follicle dermal papilla cells hair follicle dermal sheath cells epithelial cell growth basal lamina engineered skin constructs hair follicle cells skin engineering dermal fibroblasts dermal papilla cells dermal sheath cells skin cell growth skin layer skin constructs
TLDR Human hair follicle dermal cells can effectively replace other cells in engineered skin.
Researchers evaluated the potential of human hair follicle dermal cells as an alternative cell source for the dermal component of bioengineered skin constructs. They compared primary interfollicular dermal fibroblasts, hair follicle dermal papilla cells, and hair follicle dermal sheath cells in both in vitro and in vivo models. All cell types supported epithelial cell growth, but hair follicle dermal sheath cells were superior in establishing a basal lamina. The study concluded that human hair follicle dermal cells could effectively replace interfollicular fibroblasts in engineered skin constructs.
