An Improved and Rapid Method to Construct Skin Equivalents from Human Hair Follicles and Fibroblasts

    August 2001 in “ Experimental dermatology ”
    Daniela Hoeller, Berthold Huppertz, Thomas C. Roos … Frank K. Jugert
    Studysummary This study developed a rapid, cost-effective three-dimensional skin equivalent model using human dermal fibroblasts, collagen, and hair follicles, which closely resembles natural human skin and can be used for autologous transplantation.
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    Research cited in this study 5

    1. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    2. Characterization of a New Tissue-Engineered Human Skin Equivalent with Hair In Vitro Cellular & Developmental Biology - Animal · 1999
    3. Serum-Free Culture of Wool Follicles: Effects of Nutrients, Growth Factors, and Hormones British Journal of Dermatology · 1997
    4. Successful Treatment of Chronic Leg Ulcers with Epidermal Equivalents Generated from Cultured Autologous Outer Root Sheath Cells Journal of Investigative Dermatology · 1996
    5. Architecture of Reconstructed Epidermis on Collagen Lattices Varies According to the Method Used: A Comparative Study Skin Pharmacology and Physiology · 1990

    Related research 4

    1. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    2. Sheep Vibrissa Dermal Papillae Induce Hair Follicle Formation in Heterotypic Skin Equivalents British Journal of Dermatology · 1994
    3. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    4. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981