An Improved and Rapid Method to Construct Skin Equivalents from Human Hair Follicles and Fibroblasts

August 2001 in “ Experimental dermatology ”

Daniela Hoeller, Berthold Huppertz, Thomas C. Roos, Pamela Poblete Gutiérrez, Hans F. Merk, Jorge Frank, Frank K. Jugert

skin equivalents human hair follicles fibroblasts collagen dermal equivalent keratinocytes epidermis autologous transplantation skin models hair roots skin cells skin protein skin layer skin surface self-transplantation

Studysummary This study developed a rapid, cost-effective three-dimensional skin equivalent model using human dermal fibroblasts, collagen, and hair follicles, which closely resembles natural human skin and can be used for autologous transplantation.

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research Serum-Free Culture of Wool Follicles: Effects of Nutrients, Growth Factors, and Hormones

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research Architecture of Reconstructed Epidermis on Collagen Lattices Varies According to the Method Used: A Comparative Study

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This study observed that 67 kDa keratin was expressed homogeneously only in epidermis derived from hair follicle explants, differing from other culture methods where expression was delayed and patchy.