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research Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis

338 citations , July 2009 in “Development”

This study demonstrates that Sox2-positive dermal papilla cells specify particular hair follicle types by showing heterogeneity in gene expression and pathway activation in these cells.

research VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

This study found that VEGF stimulates the proliferation of human hair follicle dermal papilla cells via the VEGFR-2/ERK pathway, without involving p38, JNK, or AKT signaling.

research Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.

Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

56 citations , September 2013 in “Journal of Biochemistry and Molecular Biology”

This study observed that androgen treatment increased ROS production and TGF-β1 secretion in rat hair follicle dermal papilla cells, suggesting that the androgen-induced TGF-β1 is mediated by ROS.

research Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal–Epidermal Composites

51 citations , August 2013 in “Journal of Investigative Dermatology”

This study demonstrated that cultured human dermal papilla cells can induce full hair follicle formation when combined with neonatal foreskin keratinocytes in a grafted dermal-epidermal construct on mice.

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Community Join

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community New Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness - Paper entitled "Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type" published journal Developmental Cell

13 upvotes 11 years ago

A new treatment using dermal sheath cup cells may regrow hair and could require repeat treatments every 8 years. Users discuss ongoing trials and plan to use finasteride and minoxidil until the treatment is available.

community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

23 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

community HairClone (UK) finally begins offering its Dermal Papilla Cell Hair Multiplication procedure to humans. In Guatemala.

149 upvotes 6 months ago

HairClone is offering a Dermal Papilla Cell Hair Multiplication procedure in Guatemala, raising questions about its effectiveness and regulatory reasons for the location. Users express skepticism and curiosity about the treatment's success and potential costs.

community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

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Learn

6 / 66 results

learn SCUBE3

a signaling molecule from dermal papilla cells being actively researched

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn Platelet-Rich Plasma

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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