Central Centrifugal Cicatricial Alopecia
also CCCA
Scarring loss that starts at the crown and spreads outward, mostly in Black women
Central centrifugal cicatricial alopecia (CCCA) is a type of alopecia first noticed in African Americans in the 1950s and reported by LoPresti et al. in 1968 as a result of application of petrolatum followed by a stove-heated iron comb. The original theory was that the hot petrolatum would travel down to the hair root, burn the follicle, and after repetitive injury scarring would result. Later CCCA was realized to affect men and women without a history significant for use of such styling techniques. Consequently, the terms "follicular degeneration syndrome" per Sperling and Sau in 1992 and then CCCA per Olsent et al. in 2003 were evolved. Plausible contributing factors may include other African-American styling techniques such as relaxers, tight braids, heavy extensions, certain oils, gels or pomades.
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Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.
Research 10
- Hair grooming practices and central centrifugal cicatricial alopecia
- Treatment-Refractory Central Centrifugal Cicatricial Alopecia Responsive to a Novel Botanical Treatment
- Hair Transplantation in the Surgical Treatment of Central Centrifugal Cicatricial Alopecia
- Central Centrifugal Cicatricial Alopecia: A Survey of Treatment Practices Among Dermatology Residents and Attending Physicians
- Hair Breakage as a Presenting Sign of Early or Occult Central Centrifugal Cicatricial Alopecia
- Advances in Topical Therapies for Clinically Relevant and Prevalent Forms of Alopecia
- Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin
- The Use of Light‐Based Therapies in the Treatment of Alopecia
- Significant hair regrowth in a Middle Eastern woman with central centrifugal cicatricial alopecia
- Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib
- Central Centrifugal Cicatricial Alopecia in Black Women: Diagnostic Challenges and Molecular Insights
- Systemic Comorbidities in Central Centrifugal Cicatricial Alopecia: A Systematic Review and Meta-analysis
- Central centrifugal cicatricial alopecia in pediatric patients: A retrospective analysis
- Multidimensional burden of scarring alopecia in women: findings from the CAPAIR study
- Insulin resistance is not a predictor of response to low-dose oral metformin therapy in patients with CCCA: A retrospective review
- Trichotillomania preceding central centrifugal cicatricial alopecia in a pediatric patient
- Prevalence and incidence of primary lymphocytic cicatricial alopecias in the United States from 2019 to 2024
- The need for African dermatology guidelines—Steps towards equitable care
- Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance
- Unravelling the threads of central centrifugal cicatricial alopecia
Posts 3
- Scarring Alopecia: CCCA as a young white guy
- Starting Treatment for CCCA (scarring alopecia)
- AMA: I am an AA female in my 20s with scarring alopecia (CCCA). Three weeks ago, I received a partial HT in Istanbul, Turkey.