Sulforaphane
Sulforaphane is a naturally occurring compound found in cruciferous vegetables, such as broccoli, Brussels sprouts, and cabbage. Discovered in the 1990s, it has garnered interest for its potential health benefits, particularly its role in cancer prevention and as an antioxidant. Sulforaphane acts by inducing the production of detoxifying enzymes that protect cells from damage and inflammation. Its impact on human health has been a subject of research across various fields, including dermatology and trichology.
In the context of alopecia and hair loss, the interest in sulforaphane has recently expanded, exploring its potential benefits for hair growth and scalp health. The mechanisms through which sulforaphane may influence hair growth are thought to be multifaceted. It may help in reducing scalp inflammation, acting as an antioxidant, and potentially influencing hormonal pathways involved in hair growth cycles. Specifically, some studies suggest that sulforaphane can accelerate the degradation of dihydrotestosterone (DHT), a hormone implicated in androgenetic alopecia, thereby potentially mitigating hair loss.
Research on sulforaphane and hair growth is still in its early stages but shows promise. For instance, a study published in "Biochemical and Biophysical Research Communications" found that sulforaphane promoted hair growth in mice by accelerating the degradation of DHT, which could have implications for treating human hair loss conditions like androgenetic alopecia. Another study highlighted sulforaphane's potential in protecting skin against UV radiation damage, suggesting a broader role in skin and possibly scalp health.
The community's interest in sulforaphane as a treatment for hair loss reached a semi-hysterical peak and then seemed to die off. Some users experiment with sulforaphane, often derived from broccoli sprout extracts, as part of their treatment regimen. Community sentiment is mostly negative, acknowledging the potential of sulforaphane while recognizing the need for more robust clinical evidence to confirm its efficacy in promoting hair growth.
In summary, sulforaphane is a compound with antioxidant properties found in cruciferous vegetables, which has shown potential in promoting hair growth and protecting the scalp by mechanisms that include the modulation of DHT levels and antioxidative actions.
Research
20 / 61 results![Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation](/images/research/91b652e5-3964-4ab0-8210-23c3f6e6d719/small/19964.jpg)
research Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
![Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone](/images/research/27b014ca-160a-498f-8478-ec4ba16165ca/small/13953.jpg)
research Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone
![Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms](/images/research/a2e08966-ac46-463e-9d1c-6f94f48868df/small/26637.jpg)
research Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms
![Glucoraphanin and sulforaphane biosynthesis by melatonin mediating nitric oxide in hairy roots of broccoli (Brassica oleracea L. var. italica Planch): insights from transcriptome data](/images/research/852f2b41-d401-4c43-9c10-5c00ca58afd7/small/21266.jpg)
research Glucoraphanin and sulforaphane biosynthesis by melatonin mediating nitric oxide in hairy roots of broccoli (Brassica oleracea L. var. italica Planch): insights from transcriptome data
research Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts
![<i>Brassica oleracea</i> extract, glucosinlates, and sulforaphane promote hair growth in vitro and ex vivo](/images/research/5e7dd698-cdd3-4b68-938a-36762abb7afe/small/13149.jpg)
research Brassica oleracea extract, glucosinlates, and sulforaphane promote hair growth in vitro and ex vivo
![Oxidative Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition](/images/research/188ea4fc-0ba3-44c9-9ff5-352971a51250/small/18300.jpg)
research Oxidative Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition
![Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation](/images/research/7cded8a0-49f5-4c71-8be2-4074ab159794/small/34162.jpg)
research Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation
![Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle](/images/research/44797e18-015d-481d-8d3c-3bc76a2d8eda/small/13737.jpg)
research Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle
![Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells](/images/research/c727230d-98ad-4fb3-b3fb-d4f77b872045/small/17907.jpg)
research Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells
![1250 Development of an ex vivo human skin explant model to examine candidate gene functions in the hair follicle and epidermis](/images/research/213e2120-777d-4619-9245-e25b121f3367/small/31530.jpg)
research 1250 Development of an ex vivo human skin explant model to examine candidate gene functions in the hair follicle and epidermis
![<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>](/images/research/97af2b86-23cb-4996-a759-910a2286a1b9/small/17417.jpg)
research <p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>
![Keratin disorders: from gene to therapy](/images/research/9cf600ac-9452-40ae-b04d-0f28c28a5ef8/small/34166.jpg)
research Keratin disorders: from gene to therapy
![Baiting Proteins with C<sub>60</sub>](/images/research/1e46ccd8-1642-41ff-b712-f0f914e3fb29/small/14846.jpg)
research Baiting Proteins with C60
research Beyond Expectations
![Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment](/images/research/2090f906-78ea-4029-9336-03de13bdcb35/small/34161.jpg)
research Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment
![Oxidative stress management in the hair follicle: Could targeting NRF2 counter age‐related hair disorders and beyond?](/images/research/8deb9d99-9c88-4c30-9a73-6c86d767ceb9/small/18191.jpg)
research Oxidative stress management in the hair follicle: Could targeting NRF2 counter age‐related hair disorders and beyond?
![Biochemistry of epidermal stem cells](/images/research/1933df7c-30a6-4f88-af99-0f1daa2ed1e4/small/19798.jpg)
research Biochemistry of epidermal stem cells
![Identification of microRNAs involved in growth arrest and cell death in hydrogen peroxide-treated human dermal papilla cells](/images/research/6da249d9-f89b-4cc0-80c9-73ea0f380de5/small/29205.jpg)
research Identification of microRNAs involved in growth arrest and cell death in hydrogen peroxide-treated human dermal papilla cells
![Heme Oxygenase and the Skin in Health and Disease](/images/research/2645f0e7-3dea-46cb-ad30-fb0a666fe84e/small/17842.jpg)