Sulforaphane Mobilizes Cellular Defenses That Protect Skin Against Damage by UV Radiation

    Paul Talalay, Jed W. Fahey, Zachary R. Healy, Scott L. Wehage, Andrea L. Benedict, Changwook Min, Albena T. Dinkova‐Kostova
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    TLDR Sulforaphane from broccoli can help protect skin from sun damage.
    In 2007, researchers found that sulforaphane (SF), a compound from broccoli sprout extracts (BSE), can protect against UV radiation damage. The study included experiments on mice and a human trial with six participants (three males and three females, aged 28-53), which showed a mean reduction in UV-induced erythema of 37.7%. SF's protective effects were attributed to the activation of protective enzymes rather than UV absorption, and these effects lasted for several days. The study concluded that SF could be a potential strategy for skin cancer prevention, offering long-lasting protection without affecting vitamin D synthesis. The human studies were approved by the Institutional Review Board, and the animal studies complied with guidelines approved by the Animal Care and Use Committee.
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