Nrf2-Mediated Expansion of Pilosebaceous Cells Accelerates Cutaneous Wound Healing
December 2018
in “
The American journal of pathology
”
Studysummary This study found that genetic activation of Nrf2 in keratinocytes accelerates wound repair by enhancing cell proliferation and re-epithelialization, suggesting potential use for Nrf2-activating compounds in individuals with impaired healing.
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The study demonstrated that genetic activation of the Nrf2 transcription factor in keratinocytes significantly accelerated wound healing by promoting the proliferation of pilosebaceous cells around the wound, leading to faster re-epithelialization. This was achieved through the up-regulation of the Nrf2 target gene epigen and increased epidermal growth factor receptor signaling, resulting in a larger pool of keratinocytes migrating into the wound. The study, which involved 4 to 21 mice, suggested that Nrf2-activating compounds could be beneficial for patients with impaired healing, offering a potential therapeutic strategy for improving wound healing outcomes.
