Nrf2-Mediated Expansion of Pilosebaceous Cells Accelerates Cutaneous Wound Healing

    December 2018 in “ ˜The œAmerican journal of pathology ”
    Sukalp Muzumdar, Hayley Hiebert, Eric Haertel … Matthias Schäfer
    Studysummary This study found that genetic activation of Nrf2 in keratinocytes accelerates wound repair by enhancing cell proliferation and re-epithelialization, suggesting potential use for Nrf2-activating compounds in individuals with impaired healing.
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    Research cited in this study 6

    1. Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice EMBO molecular medicine · 2014
    2. Expression of the Orphan Protein Plet-1 During Trichilemmal Differentiation of Anagen Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    3. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    4. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    5. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    6. Delayed Wound Healing in Keratin 6a Knockout Mice Molecular and Cellular Biology · 2000