Fzd2 Controls Multiple Aspects of Epidermal Development Through Distinct Signaling Mechanisms
April 2018
in “
Journal of Investigative Dermatology
”
Hydroxypinacolone retinoate Tretinoin Nrf2 hair follicle stem cell proliferation hair follicle dermal stem cells hair loss topical tofacitinib non-scarring alopecia VEGF Fzd2 epidermal development hair follicle formation alopecia areata Th1 cytokines Th2 cytokines HPR Retin-A vascular endothelial growth factor Janus kinase inhibitor JAK inhibitor
Studysummary This study found that FZD2 is crucial for hair follicle formation and postnatal growth in mice and has a novel role in regulating early epidermal development, including stratification and cornification.
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