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GlossaryNuclear factor erythroid 2-related factor 2 (Nrf2)

regulates antioxidant proteins to protect cells from oxidative stress

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a protein that plays a crucial role in cellular defense against oxidative stress by regulating the expression of antioxidant proteins. It helps protect cells from damage caused by free radicals and other reactive molecules, which is important for maintaining healthy hair and preventing conditions like alopecia.

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research Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice

81 citations , February 2014 in “EMBO molecular medicine”

Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.

research Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition

58 citations , October 2016 in “Journal of Investigative Dermatology”

Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.

research Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?

30 citations , July 2017 in “BioEssays”

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

research The Role of Nrf2 in Hearing Loss

17 citations , April 2021 in “Frontiers in Pharmacology”

Activating Nrf2 can help protect against hearing loss.

research Nrf2-Mediated Expansion of Pilosebaceous Cells Accelerates Cutaneous Wound Healing

14 citations , December 2018 in “The American journal of pathology”

Activating Nrf2 in skin cells speeds up wound healing by increasing the growth of certain stem cells.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 3 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community What happened to the ‘funding’ for broccoli research in treating hair loss?

in Chat 43 upvotes 3 years ago

Hair loss discussion includes broccoli sprouts treatment, Fluridil 7%, and sulforaphane, with mixed results. Finasteride, minoxidil, and RU58841 are preferred by some users.