Anti-Aging Effects of Retinoid Hydroxypinacolone Retinoate on Skin Models

    April 2018 in “ Journal of Investigative Dermatology ”
    N. Ruth, T. Mammone
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    TLDR Hydroxypinacolone retinoate is a potent anti-aging ingredient for skin that is more effective and less irritating than other forms of retinoids.
    The document from 2018 reported that hydroxypinacolone retinoate (HPR) demonstrated promising anti-aging effects on skin models. HPR was more effective in increasing gene transcription levels than retinol, retinaldehyde, and retinyl palmitate, and it was less cytotoxic compared to all-trans retinoic acid (ATRA). Additionally, HPR significantly boosted pro-collagen production to levels comparable with ATRA and did not cause a greater inflammatory response than ATRA or a vehicle control. Histological analysis revealed that at the highest dose, HPR surpassed ATRA in stimulating collagen production, indicating that HPR could be a potent alternative to ATRA for anti-aging skin treatments with fewer adverse effects.
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