Anti-Aging Effects of Retinoid Hydroxypinacolone Retinoate on Skin Models

The document from 2018 reported that hydroxypinacolone retinoate (HPR) demonstrated promising anti-aging effects on skin models. HPR was more effective in increasing gene transcription levels than retinol, retinaldehyde, and retinyl palmitate, and it was less cytotoxic compared to all-trans retinoic acid (ATRA). Additionally, HPR significantly boosted pro-collagen production to levels comparable with ATRA and did not cause a greater inflammatory response than ATRA or a vehicle control. Histological analysis revealed that at the highest dose, HPR surpassed ATRA in stimulating collagen production, indicating that HPR could be a potent alternative to ATRA for anti-aging skin treatments with fewer adverse effects.