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    Glossary Cytotoxic

    substances that damage or kill cells

    Cytotoxic refers to substances or agents that are toxic to cells, meaning they can damage or kill cells. This term is often used in the context of chemotherapy drugs, which are designed to target and destroy cancer cells, but can also affect healthy cells, leading to side effects such as hair loss (alopecia).

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    1. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition Nature medicine · 2014 · 701 citations
    2. Role of Cytotoxic T Cells in Chronic Alopecia Areata Journal of Investigative Dermatology · 2000 · 127 citations
    3. Irreversible and severe alopecia following docetaxel or paclitaxel cytotoxic therapy for breast cancer 2009 · 61 citations
    4. 'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans British Journal of Dermatology · 2005 · 47 citations
    5. Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells Pharmaceutics · 2022 · 39 citations
    6. Encapsulation of Curcumin in Polystyrene-Based Nanoparticles—Drug Loading Capacity and Cytotoxicity ACS omega · 2021 · 21 citations
    7. Multiple readout assay for hormonal (androgenic and antiandrogenic) and cytotoxic activity of plant and fungal extracts based on differential prostate cancer cell line behavior Journal of Ethnopharmacology · 2014 · 19 citations
    8. The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients 2017 · 18 citations
    9. Cytotoxic Effect of YH239-EE and Its Enantiomer on MCF7 Cell Line Asian Pacific Journal of Cancer Prevention · 2024 · 13 citations
    10. Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study Clinical and Experimental Health Sciences · 2020 · 10 citations
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