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    Glossary Cytotoxic

    substances that damage or kill cells

    Cytotoxic refers to substances or agents that are toxic to cells, meaning they can damage or kill cells. This term is often used in the context of chemotherapy drugs, which are designed to target and destroy cancer cells, but can also affect healthy cells, leading to side effects such as hair loss (alopecia).

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    1. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition Nature medicine · 2014 · 701 citations
    2. Role of Cytotoxic T Cells in Chronic Alopecia Areata Journal of Investigative Dermatology · 2000 · 127 citations
    3. Irreversible and severe alopecia following docetaxel or paclitaxel cytotoxic therapy for breast cancer 2009 · 61 citations
    4. 'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans British Journal of Dermatology · 2005 · 47 citations
    5. Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells Pharmaceutics · 2022 · 39 citations
    6. Encapsulation of Curcumin in Polystyrene-Based Nanoparticles—Drug Loading Capacity and Cytotoxicity ACS omega · 2021 · 21 citations
    7. Multiple readout assay for hormonal (androgenic and antiandrogenic) and cytotoxic activity of plant and fungal extracts based on differential prostate cancer cell line behavior Journal of Ethnopharmacology · 2014 · 19 citations
    8. The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients 2017 · 18 citations
    9. Cytotoxic Effect of YH239-EE and Its Enantiomer on MCF7 Cell Line Asian Pacific Journal of Cancer Prevention · 2024 · 13 citations
    10. Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study Clinical and Experimental Health Sciences · 2020 · 10 citations
    11. Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis Journal of the European Academy of Dermatology and Venereology · 2023 · 6 citations
    12. Hypertrichosis lanuginosa acquisita following cytotoxic chemotherapy Clinical Oncology · 1992 · 4 citations
    13. Cytotoxicity and Genotoxicity of Tridax procumbens L. in Allium cepa Research Journal of Medicinal Plant · 2015 · 4 citations
    14. Cytotoxic and antioxidant effect of the ethanolic extract of Citrullus colocynthis L. plant fruit Genetics and Biodiversity Journal · 2021 · 3 citations
    15. Studying Cytotoxic T-lymphocyte- Associated Antigen-4 (CTLA-4) gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome Al-ʻulūm al-ṣaydalāniyyaẗ · 2019 · 2 citations
    16. Cytotoxicity of bendamustine, alone and in combination with novel agents, toward adult T-cell leukemia cells PLoS ONE · 2024 · 2 citations
    17. Cytotoxic Evaluation of Hair Relaxers and Straighteners Actives in Human-Derived Skin Cells Preprints.org · 2021 · 1 citations
    18. Geranyl Acetate Attenuates Para-phenylenediamine-induced Cytotoxicity, DNA Damage, Apoptosis, and Inflammation in HaCaT Keratinocytes Iranian journal of pharmaceutical research · 2025 · 1 citations
    19. 1320 Orchestrated cytotoxic and skin migratory ability lacking self-tolerance: circulating γδT-cells may promote alopecia areata Journal of Investigative Dermatology · 2018
    20. Aberrant B cell and cytotoxic T cell activation in female pattern hair loss: a pilot comparative clinico-transcriptomic study Journal of Investigative Dermatology · 2025
    21. Cytotoxic Potential of Mangifera indica L var Arumanis Rind Extract and Fraction Against T47D Cells with Microtetrazolium (MTT) Method Journal of Pharmaceutical and Health Research · 2025
    22. Antibacterial, Antioxidant, and Cytotoxic Properties of Eclipta prostrata Extracts HAYATI Journal of Biosciences · 2024
    23. Hair growth promotion, cytotoxicity and skin permeability evaluations of Carthamus tinctorius floret extract วารสารเภสัชศาสตร์อีสาน (Isan Journal of Pharmaceutical Sciences, IJPS) · 2013
    24. 599 PPARg signaling modulation protects from hair follicle bulge stem cell damage and cyclophosphamide-induced hair follicle cytotoxicity 2019
    25. Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage Brazilian Journal of Pharmaceutical Sciences · 2020
    26. Sodium chloride reduces growth and cytosolic calcium, but does not affect cytosolic pH, in root hairs of Arabidopsis thaliana L. Journal of Experimental Botany · 2003 · 69 citations
    27. Sulfation of minoxidil by multiple human cytosolic sulfotransferases Chemico-Biological Interactions · 1998 · 59 citations
    28. Cytologic Atypia in a 53-Year-Old Man With Finasteride-Induced Gynecomastia Archives of Pathology & Laboratory Medicine · 2000 · 7 citations
    29. Cytologic atypia in a 53-year-old man with finasteride-induced gynecomastia. Archives of Pathology & Laboratory Medicine · 2000 · 7 citations
    30. Cytologic Aspect of Keratoacanthoma with Granulomatous Inflammation in a Dog Journal of Veterinary Clinics · 2009