Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity

January 2014 in “ International review of cell and molecular biology ”

Melanie Homberg, Thomas M. Magin

keratin epidermis cytoskeletal scaffolds tissue homeostasis keratin genes skin disorders cytoarchitecture epithelial cells

Studysummary This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discusses the critical role of keratin intermediate filament proteins in maintaining the integrity of the epidermis, which is essential for protecting the body. Keratins form cell-specific cytoskeletal scaffolds that are vital for cell and tissue stability, and their expression and organization can change in response to stress to maintain tissue homeostasis. However, mutations in keratin genes can lead to acute and chronic skin disorders, for which there are no effective treatments currently available. The review highlights recent advancements in understanding how keratins contribute to the epidermis's cytoarchitecture, adhesion, signaling, and inflammation, emphasizing the importance of keratin isotypes in the functions of differentiated epithelial cells.

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