Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility

    July 2009 in “ ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation ”
    Pierre A. Coulombe, Michelle L. Kerns, Elaine Fuchs
    Studysummary This review discusses how research on keratin biology has enhanced the understanding of epidermolysis bullosa simplex and indicates potential new therapeutic approaches, but it presents no new experimental results.
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    Research cited in this study 5

    1. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    2. Recessive Epidermolysis Bullosa Simplex Phenotype Reproduced In Vitro American Journal Of Pathology · 2003
    3. Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia Genes & Development · 2002
    4. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 ˜The œjournal of cell biology/˜The œJournal of cell biology · 1999
    5. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989