Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins

The document "Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins" explores how environmental factors like ultraviolet radiation, heavy metals, organic solvents, and dietary contaminants contribute to genomic disruptions in cytokeratins, essential proteins in epithelial tissues. These disruptions can lead to various skin disorders, including keratinopathies, epidermolysis bullosa, keratinopathic ichthyosis, and monilethrix. The study also discusses hair and nail disorders linked to keratin gene mutations, such as Pseudofolliculitis Barbae, loose anagen hair syndrome, and Pachyonychia congenital. The research emphasizes the significant role of environmental mutagens in causing DNA damage and highlights the need for further research on their genetic and epigenetic effects to develop better preventive and therapeutic strategies.