Skin Keratins

    November 2015 in “ Methods in enzymology on CD-ROM/Methods in enzymology ”
    Feng-Rong Wang, Abigail Zieman, Pierre A. Coulombe
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    TLDR Keratins are important for skin cell health and their problems can cause diseases.
    Keratins, which are type I and type II intermediate filament-forming proteins found in epithelial cells, are encoded by 54 genes and are regulated in a specific manner depending on the tissue type, differentiation, and context. They play a crucial role in maintaining cellular integrity, regulating cell growth and migration, and protecting against apoptosis, with their functions being regulated by posttranslational modifications and keratin-associated proteins. Genetic mutations in keratin genes can lead to rare but highly penetrant disorders characterized by cell fragility and altered tissue homeostasis. Additionally, keratin mutations or misregulation can act as risk factors or genetic modifiers for various acute and chronic diseases. The document specifically focuses on skin epithelia keratins and outlines basic protocols and assays for skin analyses.
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