Skin Keratins

    Feng-Rong Wang, Abigail Zieman, Pierre A. Coulombe
    Image of study
    TLDR Keratins are important for skin cell health and their problems can cause diseases.
    Keratins, which are type I and type II intermediate filament-forming proteins found in epithelial cells, are encoded by 54 genes and are regulated in a specific manner depending on the tissue type, differentiation, and context. They play a crucial role in maintaining cellular integrity, regulating cell growth and migration, and protecting against apoptosis, with their functions being regulated by posttranslational modifications and keratin-associated proteins. Genetic mutations in keratin genes can lead to rare but highly penetrant disorders characterized by cell fragility and altered tissue homeostasis. Additionally, keratin mutations or misregulation can act as risk factors or genetic modifiers for various acute and chronic diseases. The document specifically focuses on skin epithelia keratins and outlines basic protocols and assays for skin analyses.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 139 results

      community I’m Quitting ketoconazole shampoo

      in Ketoconazole  2 upvotes 1 year ago
      A user is quitting ketoconazole shampoo, believing it worsened their hair condition, and plans to use clarifying, keratin, and pH balanced moisturizing shampoos instead. Another user suggests using conditioner after ketoconazole to prevent dryness.

      community Let's talk keratin products and hair loss

      in Styling  2 upvotes 5 days ago
      OP is considering using a keratin gel to improve hair quality and is concerned about its safety and visual impact on a slightly balding crown. Users discuss shampoo frequency, with some suggesting less frequent use for better hair health, but OP prefers regular shampoo and conditioner for silky hair.

      community Well here I am 3-4 years later.

      in Update  56 upvotes 1 year ago
      The conversation is about someone who has been taking finasteride for hair loss without success, considering switching to dutasteride or giving up treatment. Suggestions include trying dutasteride, microneedling, infrared therapy, multivitamins, and high-concentration topical solutions combining finasteride and dutasteride.

    Related Research

    1 / 1 results