Skin Keratins

November 2015 in “ Methods in enzymology on CD-ROM/Methods in enzymology ”

Feng-Rong Wang, Abigail Zieman, Pierre A. Coulombe

keratins type I intermediate filament type II intermediate filament epithelial cells keratin genes posttranslational modifications keratin-associated proteins genetic mutations cell fragility tissue homeostasis skin epithelia skin keratins intermediate filaments epithelial keratins

Studysummary This chapter reviews keratins in skin epithelia, including their roles in cellular function and disease, and reports no new experimental results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

12 / 12 results

research Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice

15 citations , May 2014 in “Journal of Biological Chemistry”

In this study, targeting the expression of a keratin KRT5/KRT8 chimeric cDNA in keratin-deficient mice partially restored structural defects in epidermal cells, but did not fully normalize skin health.

research The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia

186 citations , December 2012 in “Current opinion in cell biology”

This review discusses the recent advancements in understanding how keratins influence cytoarchitecture, cell dynamics, and disease processes but reports no new clinical results; the authors highlight its roles in development and diseases like cancer.

research Keratins And Disease At A Glance

87 citations , September 2012 in “Journal of Cell Science”

This review discusses the role of keratins in providing mechanical resilience to epithelial tissues and highlights recent therapeutic approaches for keratin diseases, but reports no new experimental findings.

research Keratin Disorders: From Gene to Therapy

109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”

This review discusses keratin disorders and potential RNA interference therapeutics, reporting no new clinical findings but highlighting the promise of siRNA for future treatments.

research Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice

427 citations , April 2008 in “Nature Protocols”

research Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion

169 citations , May 2006 in “Genes & Development”

This study found that keratin 17 and TNFα play interdependent roles in regulating hair follicle cycling, with TNFα required for the anagen–catagen transition and its ablation partially rescuing hair cycling defects in K17-null mice.

research A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n, Exhibits Preferred Expression in Nail Tissue

31 citations , April 2004 in “Journal of Investigative Dermatology”

This study found that a newly identified gene, mK17n, may explain the lack of nail issues in mK17 null mice by compensating for mK17's function in the nail bed.

research Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles

60 citations , December 2003 in “Journal of Investigative Dermatology”

This study found that keratin 6hf, a type II keratin, is expressed in specific regions of mouse and human hair and suggests potential interactions with keratin 17, impacting hair development and associated disorders.

research Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle

87 citations , November 2002 in “Journal of Investigative Dermatology”

research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development

318 citations , October 1998 in “The Journal of Cell Biology”

This study found that ectopic expression of the lymphoid-enhancer factor can induce K17 protein in the skin, suggesting a link between skin development and wound repair processes in mice.

research The Two Functional Keratin 6 Genes of Mouse Are Differentially Regulated and Evolved Independently from Their Human Orthologs

79 citations , October 1998 in “Genomics”

This study found that the mK6alpha and mK6beta genes in mice are regulated differently at the mRNA level, with implications for understanding K6 gene evolution and function in mammals.

research Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage

441 citations , May 1996 in “Journal of Cell Science”

This study found that keratin 19 may be a marker for skin stem cells, helping to characterize these cells in different conditions and potentially explaining variations in healing rates between children and adults.