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GlossaryPost-Translational Modifications

chemical changes to proteins after synthesis affecting their function

Post-Translational Modifications (PTMs) refer to the chemical changes that proteins undergo after they are synthesized in a cell. These modifications can include the addition of phosphate groups, sugars, or lipids, and they play a crucial role in regulating protein function, stability, and interactions. PTMs are essential for the proper functioning of proteins and can impact various biological processes, including cell signaling, immune responses, and hair growth.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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research Types I and II Keratin Intermediate Filaments

211 citations, April 2018 in “Cold Spring Harbor Perspectives in Biology”

Keratins are crucial for cell structure, growth, and disease risk.

research Skin Keratins

54 citations, November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology”

Keratins are important for skin cell health and their problems can cause diseases.

Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

research Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

38 citations, October 2011 in “Analytical biochemistry”

Hair proteins have weak spots in their α-helical segments.

research Keratin Function and Regulation in Tissue Homeostasis and Pathogenesis

7 citations, April 2012 in “Biomolecular concepts”

Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.

research A General Mathematical Model for the In Vitro Assembly Dynamics of Intermediate Filament Proteins

5 citations, February 2022 in “Biophysical journal”

The model shows that filament flexibility and amino acid differences affect how fast intermediate filament proteins assemble.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 123 upvotes 1 year ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.