Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments

October 2011 in “ Analytical biochemistry ”

Nicolas R. Barthélemy, Audrey Bednarczyk, Christine Schaeffer-Reiss, Dominique Jullien, Alain Van Dorsselaer, Nükhet Cavusoglu

proteomic mass spectrometry multidimensional protein identification technology MudPit two-dimensional gel electrophoresis 2-DE gel MS human hair cortex proteins keratins keratin-associated proteins KAPs posttranslational modifications cysteine trioxidation lysine methylation histidine methylation α-helical segments hair keratins proteomic MS hair proteins cysteine oxidation alpha-helical segments

Studysummary This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.

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