TLDR Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.
The study characterized KAP24.1, a novel keratin-associated protein found exclusively in human scalp hair, revealing its unique amino acid composition with high serine, proline, and tyrosine but low cysteine content. KAP24.1 featured distinctive carboxyterminal tyrosine-containing tandem decameric repeats and was distinct from other KAP family members. Expression studies confirmed its specific localization in the middle/upper hair cuticle, suggesting a specialized role in hair structure and integrity.
Cited in this study
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53 citations
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June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” KAP genes show significant genetic variability, but its impact on hair traits is unclear.
6 citations
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May 2005 in “Journal of dermatological science” The study found nine new hair protein genes in human hair follicles.
479 citations
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January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
62 citations
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January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.
100 citations
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December 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.
98 citations
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June 2001 in “Journal of biological chemistry/The Journal of biological chemistry” A cluster of sulfur-rich hair protein genes was found on chromosome 17.
74 citations
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October 1998 in “Journal of biological chemistry/The Journal of biological chemistry” The 190-kbp domain contains all human type I hair keratin genes, showing their organization and evolution.
