Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino Acid Composition and Repeat Structure

January 2007 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Michael A. Rogers, Hermelita Winter, Lutz Langbein, Anke Wollschläger, Silke Praetzel-Wunder, Luis F Jave-Suárez, Jürgen Schweizer

KAP24.1 keratin-associated protein serine proline tyrosine cysteine hair cuticle hair structure hair integrity keratin hair protein

TLDR Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.

The study characterized KAP24.1, a novel keratin-associated protein found exclusively in human scalp hair, revealing its unique amino acid composition with high serine, proline, and tyrosine but low cysteine content. KAP24.1 featured distinctive carboxyterminal tyrosine-containing tandem decameric repeats and was distinct from other KAP family members. Expression studies confirmed its specific localization in the middle/upper hair cuticle, suggesting a specialized role in hair structure and integrity.

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