Identification of Two Novel Clusters of Ultrahigh-Sulfur Keratin-Associated Protein Genes on Human Chromosome 11

April 2004 in “ Biochemical and Biophysical Research Communications ”

Shoichi Yahagi, Kazunori Shibuya, Izumi Obayashi, Hitoshi Masaki, Yoshiko Kurata, Jun Kudoh, Nobuyoshi Shimizu

TLDR Two new gene clusters important for hair formation were found on human chromosome 11.

The study identified two novel clusters of keratin-associated protein (KAP) genes on human chromosome 11, specifically at 11p15.5 and 11q13.5. These clusters included two known KRTAP5 genes and nine novel KRTAP5 family genes, all classified as ultrahigh-sulfur (UHS) type KAPs due to their high cysteine content. The genes showed preferential expression in human hair roots, indicating their role in hair formation. The study suggested that these gene clusters were generated through genomic duplication and subsequent genetic modification.

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