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GlossaryUncombable Hair Syndrome (UHS)

rare genetic condition causing frizzy, unmanageable hair with unique shaft structure

Uncombable Hair Syndrome (UHS), also known as Pili Trianguli et Canaliculi or Spun Glass Hair, is a rare genetic condition characterized by dry, frizzy hair that stands out from the scalp and cannot be combed flat. The hair shafts are uniquely structured with a triangular or heart-shaped cross-section and a longitudinal groove, making them resistant to being styled or managed.

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research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

119 citations , November 2016 in “American journal of human genetics”

Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.

research Uncombable Hair Improved by Biotin

February 2023 in “JEADV Clinical Practice”

Biotin supplements significantly improved a young girl's uncombable hair.

research Hair Cross-Sectioning in Uncombable Hair Syndrome: An Easy Tool for Complex Diagnosis

7 citations , June 2018 in “Journal of the American Academy of Dermatology”

The document suggests finding a simpler, cheaper way to diagnose Uncombable Hair Syndrome.

research Uncombable Hair Syndrome and Beyond

January 2022 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

Uncombable hair syndrome causes frizzy hair and can affect the nervous system, eyes, and ears, often co-occurring with other hair, skin, nail, and teeth conditions, and is linked to three specific gene mutations.

research A Case of Localized Uncombable Hair Syndrome

April 2016 in “Journal of the American Academy of Dermatology”

A 4-year-old girl had a rare hair disorder affecting only part of her scalp.

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