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GlossaryUncombable Hair Syndrome (UHS)

rare genetic condition causing frizzy, unmanageable hair with unique shaft structure

Uncombable Hair Syndrome (UHS), also known as Pili Trianguli et Canaliculi or Spun Glass Hair, is a rare genetic condition characterized by dry, frizzy hair that stands out from the scalp and cannot be combed flat. The hair shafts are uniquely structured with a triangular or heart-shaped cross-section and a longitudinal groove, making them resistant to being styled or managed.

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research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

119 citations, November 2016 in “American journal of human genetics”

Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.

research Structure and Expression of Genes for a Class of Cysteine-Rich Proteins of the Cuticle Layers of Differentiating Wool and Hair Follicles

67 citations, December 1990 in “The journal of cell biology/The Journal of cell biology”

Researchers found genes for cysteine-rich proteins that form the protective layer of hair in humans and sheep.

research Hair Cross-Sectioning in Uncombable Hair Syndrome: An Easy Tool for Complex Diagnosis

7 citations, June 2018 in “Journal of the American Academy of Dermatology”

The document suggests finding a simpler, cheaper way to diagnose Uncombable Hair Syndrome.

research Spontaneous Quick Resolution of Uncombable Hair Syndrome-Like Disease

2 citations, October 2018 in “Skin appendage disorders”

A boy's hair that was frizzy and hard to comb returned to normal after 9 months, possibly due to genetic factors.

research Uncombable Hair Improved by Biotin

February 2023 in “JEADV Clinical Practice”

Biotin supplements significantly improved a young girl's uncombable hair.

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