Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression

    April 2016 in “ PloS one ”
    Zhichao Zhao, Guangbin Liu, Xinyun Li, Ji Huang, Yujing Xiao, Xiaoyong Du, Mei Yu
    TLDR The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.
    The study characterized the promoter regions of two sheep keratin-associated protein genes, KRTAP3-3 and KRTAP11-1, to understand their role in hair cortex-specific expression. Researchers found that the KRTAP11-1 promoter directed strong and uniform expression in the hair cortex of transgenic mice, while KRTAP3-3 showed variable expression. Key regulatory elements in the KRTAP11-1 promoter were identified, suggesting its potential for targeted gene expression in hair. These findings provided insights into the genetic mechanisms controlling hair fiber formation, which could improve wool quality in sheep.
    Discuss this study in the Community →

    Research cited in this study

    20 / 20 results

    Related Community Posts Join

    6 / 159 results

      community Keratin microspheres - breakthrough

      in Research/Science  15 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Comprehensive Microneedling Guide

      in Microneedling  288 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  12 upvotes 5 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Dec 2024 vs now (min + fin/dut)

      in Progress Pictures  26 upvotes 2 weeks ago
      The user experienced hair thickening and reduced shedding using minoxidil, finasteride, and dutasteride, with a switch from finasteride to dutasteride due to ineffectiveness. They also use a saw palmetto shampoo and take vitamin D3 supplements, while considering potential underlying causes like vitamin deficiencies and hard water buildup.

    Related Research

    1 / 1 results