Targeted Expression of SV40 T Antigen in the Hair Follicle of Transgenic Mice Produces an Aberrant Hair Phenotype

    March 1995 in “ Journal of cell science ”
    B. Powell R. Keough, George E. Rogers
    Studysummary This study found that targeting SV40 T antigen expression to hair follicles in transgenic mice caused abnormal hair structure and hair loss, but did not lead to cell immortalization or tumor formation in follicles.
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    Research cited in this study 12

    1. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and In Transgenic Mice Molecular and Cellular Biology · 1993
    2. Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation The Journal of Cell Biology · 1993
    3. Hair Follicle Differentiation: Expression, Structure, and Evolutionary Conservation of the Hair Type II Keratin Intermediate Filament Gene Family Development · 1992
    4. Regulation of Keratin Gene Expression in Hair Follicle Differentiation Annals of the New York Academy of Sciences · 1991
    5. An In Vitro Model for the Study of Human Hair Growth Annals of the New York Academy of Sciences · 1991
    6. Cyclic Hair Loss and Regrowth in Transgenic Mice Overexpressing an Intermediate Filament Gene The EMBO Journal · 1990
    7. Hard Keratin Intermediate Filaments and Associated Proteins 1990
    8. The Proteins of Hair and Other Hard Alpha-Keratins 1990
    9. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum) Differentiation · 1988
    10. Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix Journal of Investigative Dermatology · 1987
    11. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986
    12. The Structure of Hair and Follicles of Mice Carrying the Naked (N) Gene Genetics Research · 1982

    Related research 5

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