Krtap11-1, A Hair Keratin-Associated Protein, As A Possible Crucial Element For The Physical Properties Of Hair Shafts

January 2014 in “ Journal of Dermatological Science ”

Shunsuke Fujimoto, Takahisa Takase, Nanako Kadono, Kenji Maekubo, Yohei Hirai

Krtap11-1 keratin-associated protein keratin disulfide cross-links keratinocytes hair cortex hair follicle development keratin-bundle assembly hair protein hair shaft

Studysummary This study found that Krtap11-1 may play an important role in keratin-bundle assembly in the hair cortex, influencing the physical properties of hair. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the role of Krtap11-1, a keratin-associated protein, in hair development and its physical properties. It was found that Krtap11-1 expression was asymmetrically distributed in faulty hair of Foxn1nu mice and was regulated by the keratinization process and proteasome-dependent protein elimination in cultured keratinocytes. Krtap11-1 was shown to associate with keratin and self-assemble through disulfide cross-links, and it could adhere to certain type I keratins in the hair cortex without disulfide formation. Forcible expression of Krtap11-1 in embryonic upper lip rudiments led to irregular hair follicle development, suggesting its significant role in keratin-bundle assembly and influencing the physical properties of hair shafts.

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