TLDR The C-terminal tail of AHF/trichohyalin is essential for organizing keratin filaments in keratinocytes.
The study identified the C-terminal tail domain of AHF/trichohyalin as crucial for modulating the keratin filamentous meshwork in keratinocytes. By introducing full-length and mutant AHF into keratinocyte cell lines, researchers observed that the full-length AHF formed small granules that bound to keratin filaments, affecting cell growth, mobility, and shape. Removing 6 amino acids from the C-terminal tail resulted in a loss of keratin adherence and enlarged granules. The findings suggested that AHF's C-terminus latches onto keratin bundles, rearranging the keratin meshwork through its cohesive activity, providing insights into cytoskeletal modulation in hair follicles.
35 citations,
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