Trichohyalin Mechanically Strengthens the Hair Follicle

    October 2003 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Peter M. Steinert, David Parry, Lyuben N. Marekov
    Studysummary This study documents that trichohyalin acts as a multi-functional cross-bridging protein in the inner root sheath of mouse hair follicles, enhancing mechanical strength by linking keratin filaments to the cell envelope.
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    Research cited in this study 20

    1. Epithelial Barrier Function: Assembly and Structural Features of the Cornified Cell Envelope BioEssays · 2002
    2. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002
    3. Cryo-Electron Microscopy of Trichocyte (Hard Alpha-Keratin) Intermediate Filaments Reveals a Low-Density Core Journal of Structural Biology · 2002
    4. Genes for Intermediate Filament Proteins and the Draft Sequence of the Human Genome Journal of Cell Science · 2001
    5. A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001
    6. A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles Journal of Investigative Dermatology · 2001
    7. Human Peptidylarginine Deiminase Type III: Molecular Cloning and Nucleotide Sequence of the cDNA, Properties of the Recombinant Enzyme, and Immunohistochemical Localization in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2000
    8. Biochemical Evidence That Small Proline-Rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes Journal of biological chemistry/˜The œJournal of biological chemistry · 1998
    9. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997
    10. Existence of Trichohyalin-Keratohyalin Hybrid Granules: Co-Localization of Two Major Intermediate Filament-Associated Proteins in Non-Follicular Epithelia Differentiation · 1994
    11. Apoptosis in Human Skin Development: Morphogenesis, Periderm, and Stem Cells Developmental dynamics · 1994
    12. Trichohyalin: A Structural Protein of Hair, Tongue, Nail, and Epidermis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    13. The Structure of Human Trichohyalin: Potential Multiple Roles as a Functional EF-Hand-Like Calcium-Binding Protein, a Cornified Cell Envelope Precursor, and an Intermediate Filament-Associated (Cross-Linking) Protein Journal of Biological Chemistry · 1993
    14. Analysis of the Sheep Trichohyalin Gene: Potential Structural and Calcium-Binding Roles of Trichohyalin in the Hair Follicle The Journal of Cell Biology · 1993
    15. Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1991
    16. Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986
    17. Structural Features of the Alpha-Type Filaments of the Inner Root Sheath Cells of the Guinea Pig Hair Follicle Biochemistry · 1978
    18. Formation of the Iε-(γ-Glutamyl)Lysine Crosslink in Hair Proteins: Investigation of Transamidases in Hair Follicles Biochemistry · 1972
    19. Iε-(γ-Glutamyl) Lysine Cross-Linkage in Citrulline-Containing Protein Fractions From Hair Biochemistry · 1971
    20. The Localization And Significance Of Arginine And Citrulline In Proteins Of The Hair Follicle Journal of Histochemistry & Cytochemistry · 1963

    Related research 7

    1. Molecular Elements of the Regulatory Control of Keratin Filament Modulator AHF/Trichohyalin in the Hair Follicle Experimental Dermatology · 2008
    2. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    3. On The Regulation Of Hair Keratin Expression: Lessons From Studies In Pilomatricomas Journal of Investigative Dermatology · 2004
    4. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    5. Cell Kinetics of the Human Hair Follicle Clinics in dermatology · 1988
    6. Specific Keratins And Their Associated Proteins As Markers For Hair Follicle Differentiation 1988
    7. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981