Biochemical Evidence That Small Proline-Rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes

    May 1998 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Peter M. Steinert, Tonja Kartašova, Lyuben N. Marekov
    TLDR Small proline-rich proteins and trichohyalin help make epithelial tissues tougher and more flexible.
    The study provided biochemical evidence that small proline-rich proteins (SPRs) and trichohyalin (THH) played crucial roles in modulating the biomechanical properties of cornified cell envelopes (CEs) in epithelia. SPRs functioned as cross-bridging proteins, forming interchain cross-links with other CE proteins such as loricrin, envoplakin, involucrin, and keratin 1, enhancing the structural integrity and toughness of tissues like the forestomach. The research showed that the amount of SPRs varied according to the physical requirements of the tissues, suggesting a significant role for SPRs and THH in determining the biomechanical properties of epithelia.
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