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Glossary Cornified Envelope

tough, protective layer in the outermost skin part

The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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research The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

161 citations , June 1993 in “Journal of Biological Chemistry”

This study suggests that human trichohyalin may function as a flexible rod linking keratin intermediate filaments and as a scaffold protein in hair follicle and epidermis cell envelopes.

research Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes

99 citations , May 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that small proline-rich proteins modify the biomechanical properties of cornified cell envelopes in rodent forestomachs, potentially affecting the tissue's ability to withstand mechanical stress.

research Epithelial barrier function: assembly and structural features of the cornified cell envelope

425 citations , August 2002 in “BioEssays”

This review discusses the structure and assembly of the cornified cell envelope in stratified squamous epithelial cells and various disorders leading to barrier defects, but reports no new findings.

research The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

2 citations , January 1993

This study found that human trichohyalin has a unique protein sequence potentially contributing to at least three important functions in hair follicle and epidermal cells.

research [Difference between the hair follicle cell and epidermal keratinocyte in vitro].

February 1990 in “PubMed”

This study suggests that human hair follicle cells and epidermal keratinocytes differ in their degree of keratinization and other characteristics when cultured on mixed collagen membranes.

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community Mallia Aesthetics achieves key regulatory steps for novel sCD83-derived ingredient for hair growth

24 upvotes 1 year ago

Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hair growth without disrupting the skin microbiome. sCD83 promotes hair growth by activating hair follicles and preventing cell death, offering a localized treatment without systemic side effects.

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