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GlossaryCornified Envelope

tough, protective layer in the outermost skin part

The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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research Biochemical Evidence That Small Proline-Rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes

99 citations, May 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Small proline-rich proteins and trichohyalin help make epithelial tissues tougher and more flexible.

research The Expression of Vitamin D-Upregulated Protein 1 in Skin and Its Interaction with Sciellin in Cultured Keratinocytes

18 citations, September 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

VDUP1 is found in skin and hair follicles, interacts with sciellin, and may help regulate skin cell differentiation.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations, August 2020 in “Cells”

TGM3 is important for skin and hair structure and may help diagnose cancer.

research Developing Stratified Epithelia: Lessons from the Epidermis and Thymus

27 citations, August 2014 in “Wiley interdisciplinary reviews. Developmental biology”

The skin and thymus develop similarly to protect and support immunity.

research Cross-Linked Features of Mouse Pelage Hair Resistant to Detergent Extraction

15 citations, February 1999 in “The anatomical record”

Some mutant mice have hair with abnormal cross-linking, mainly in the cuticle, not affecting other hair parts.

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community Long term finasteride users; Did you notice any improvement after 2 years?

in Finasteride/Dutasteride 14 upvotes 1 year ago

Long term Finasteride users and whether or not they have noticed improvements after two years of use, with other treatments such as Minoxidil and dermarolling also discussed. Some replies suggest that improvement is possible even beyond the two year mark while others caution against believing studies backed by the Post-Finasteride Foundation.

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

in Finasteride/Dutasteride 184 upvotes 2 weeks ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community 3 months progress with Finasteride 0.5mg/daily, Minoxidil foam5% 2x daily, Stemoxydine 2x daily, Microneedling(M8) 1.5mm 1x per week, Saw Palmetto 400mg/day, peppermint and jojoba oils daily, Ketoconazole 2% shampoo 3x/week, Purador shampoo/conditioner every day.

in Progress Pictures 337 upvotes 2 years ago

Jordan-Iliad has been using a combination of finasteride, minoxidil, stemoxydine, microneedling, saw palmetto, peppermint and jojoba oils, ketoconazole shampoo, and Purador shampoo/conditioner for 3 months to treat their hair loss with stunning results. They have also recently started taking oral minoxidil 1.25mg/day in hopes of achieving even better results over the next 3 months.

community Certified old, at 51, balding since 25, the resurrection!

in Progress Pictures 439 upvotes 3 weeks ago

A 51-year-old shared progress on hair regrowth using topical Minoxidil and Finasteride over four months, noting significant improvement and plans for future hair transplants. The user emphasized the benefits of modern treatments and societal changes in attitudes towards hair loss.

community I just went to a dermatologist and there were many red flags about him.

in Treatment 13 upvotes 1 year ago

A user visited a dermatologist for hair loss concerns and was prescribed a hair lotion called "Lotion revolotion evdermia," which is meant for hair toning, hydration, and anti-aging, not regrowth. The user found the dermatologist's behavior and the prescription to be questionable.

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