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    Glossary Cornified Envelope

    tough, protective layer in the outermost skin part

    The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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    1. The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein Journal of Biological Chemistry · 1993 · 161 citations
    2. Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes 1998 · 99 citations
    3. Epithelial barrier function: assembly and structural features of the cornified cell envelope BioEssays · 2002 · 425 citations
    4. The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein 1993 · 2 citations
    5. [Difference between the hair follicle cell and epidermal keratinocyte in vitro]. PubMed · 1990
    6. Formation of the cornified envelope Experimental dermatology · 2005 · 3 citations
    7. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001 · 130 citations
    8. Transglutaminase 5 Expression in Human Hair Follicle Journal of Investigative Dermatology · 2005 · 28 citations
    9. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    10. Trichohyalin Mechanically Strengthens the Hair Follicle 2003 · 108 citations
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