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GlossaryCornified Envelope

tough, protective layer in the outermost skin part

The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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research Biochemical Evidence That Small Proline-Rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes

99 citations , May 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Small proline-rich proteins and trichohyalin help make epithelial tissues tougher and more flexible.

research The Expression of Vitamin D-Upregulated Protein 1 in Skin and Its Interaction with Sciellin in Cultured Keratinocytes

18 citations , September 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

VDUP1 is found in skin and hair follicles, interacts with sciellin, and may help regulate skin cell differentiation.

research Transglutaminase 5 Expression in Human Hair Follicle

28 citations , August 2005 in “Journal of Investigative Dermatology”

TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations , August 2020 in “Cells”

TGM3 is important for skin and hair structure and may help diagnose cancer.

research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

100 citations , May 2006 in “American Journal Of Pathology”

Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.

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community Mallia Aesthetics achieves key regulatory steps for novel sCD83-derived ingredient for hair growth

in Research/Science 23 upvotes 3 months ago

Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hair growth without disrupting the skin microbiome. sCD83 promotes hair growth by activating hair follicles and preventing cell death, offering a localized treatment without systemic side effects.

community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 8 months ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

community Long term finasteride users; Did you notice any improvement after 2 years?

in Finasteride/Dutasteride 14 upvotes 2 years ago

Long term Finasteride users and whether or not they have noticed improvements after two years of use, with other treatments such as Minoxidil and dermarolling also discussed. Some replies suggest that improvement is possible even beyond the two year mark while others caution against believing studies backed by the Post-Finasteride Foundation.

community Hair loss research is a money grab

in Chat 217 upvotes 2 weeks ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community Dermatologist says you can’t prevent hair loss and medications don’t work

in Research/Science 142 upvotes 1 month ago

Finasteride, dutasteride, and minoxidil can help prevent or slow hair loss for many, though results vary. The dermatologist's claim that no medication works is incorrect, as these treatments are effective for some individuals.

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