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    Glossary Cornified Envelope

    tough, protective layer in the outermost skin part

    The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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    1. The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein Journal of Biological Chemistry · 1993 · 161 citations
    2. Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes 1998 · 99 citations
    3. Epithelial barrier function: assembly and structural features of the cornified cell envelope BioEssays · 2002 · 425 citations
    4. The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein 1993 · 2 citations
    5. [Difference between the hair follicle cell and epidermal keratinocyte in vitro]. PubMed · 1990
    6. Formation of the cornified envelope Experimental dermatology · 2005 · 3 citations
    7. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001 · 130 citations
    8. Transglutaminase 5 Expression in Human Hair Follicle Journal of Investigative Dermatology · 2005 · 28 citations
    9. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    10. Trichohyalin Mechanically Strengthens the Hair Follicle 2003 · 108 citations
    11. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    12. Lysine Carboxymethyl Cysteinate (LCC) Protects the Epidermis from UVB-Induced Barrier Damage Through the Activation of Autophagy Biology · 2026
    13. Novel insights into hair structure and the effects of chemical stressors on hair and skin using label-free advanced light microscopy Durham e-Theses (Durham University) · 2017
    14. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    15. The effects of minoxidil on postconfluent human hair follicle cells. The Nishinihon Journal of Dermatology · 1989 · 1 citations
    16. Quoi de neuf en recherche dermatologique ? Annales de Dermatologie et de Vénéréologie · 2011 · 2 citations
    17. Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function Cell Death and Disease · 2015 · 17 citations
    18. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    19. Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes Differentiation · 1992 · 64 citations
    20. Involucrin: A Constituent of Cross-Linked Envelopes and Marker of Squamous Maturation 1986 · 23 citations
    21. Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types Journal of Veterinary Science · 2012 · 15 citations
    22. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    23. Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)–Deficient Canines American Journal Of Pathology · 2018 · 21 citations
    24. Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid Archives of Dermatology · 2000 · 74 citations
    25. Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy International journal of trichology · 2010 · 10 citations
    26. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    27. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005 · 77 citations
    28. Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2 2022 · 8 citations
    29. Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer Cells · 2020 · 22 citations
    30. Establishment of keratinocyte cell lines from human hair follicles Scientific reports · 2018 · 16 citations