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    Glossary Cornified Envelope

    tough, protective layer in the outermost skin part

    The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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    1. Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes Differentiation · 1992 · 64 citations
    2. Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes Experimental Dermatology · 2019 · 44 citations
    3. Formation of the cornified envelope Experimental dermatology · 2005 · 3 citations
    4. Epithelial barrier function: assembly and structural features of the cornified cell envelope BioEssays · 2002 · 425 citations
    5. The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein Journal of Biological Chemistry · 1993 · 161 citations
    6. Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes 1998 · 99 citations
    7. The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein 1993 · 2 citations
    8. Involucrin: A Constituent of Cross-Linked Envelopes and Marker of Squamous Maturation 1986 · 23 citations
    9. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    10. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
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