TLDR Understanding how EDC genes are regulated can help develop better drugs for skin diseases.
The review discussed the role of the epidermal differentiation complex (EDC) genes in the development of the mammalian skin's protective layer, which includes hair follicles, inter-follicular epidermis, and sebaceous glands. These genes, located on human chromosome 1q21, are crucial for the orderly process of epidermal proliferation and differentiation, leading to the formation of the cornified envelope. The regulation of these processes involves various chromatin remodeling factors and epigenetic modifiers. Dysregulation of these mechanisms is linked to diseases like psoriasis and cancer. Understanding these regulatory mechanisms could aid in drug development and improve existing drug delivery systems.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
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January 2018 in “Stem cell biology and regenerative medicine” ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.
86 citations,
August 2011 in “Toxicological sciences” TCDD speeds up skin barrier formation by increasing certain gene expressions.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
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January 2018 in “Stem cell biology and regenerative medicine” The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.
11 citations,
June 2022 in “Frontiers in immunology” New protein changes may be involved in the immune attack on hair follicles in alopecia areata.
