Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets

The review discussed the role of the epidermal differentiation complex (EDC) genes in the development of the mammalian skin's protective layer, which includes hair follicles, inter-follicular epidermis, and sebaceous glands. These genes, located on human chromosome 1q21, are crucial for the orderly process of epidermal proliferation and differentiation, leading to the formation of the cornified envelope. The regulation of these processes involves various chromatin remodeling factors and epigenetic modifiers. Dysregulation of these mechanisms is linked to diseases like psoriasis and cancer. Understanding these regulatory mechanisms could aid in drug development and improve existing drug delivery systems.