All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration
January 2018
in “
Stem cell biology and regenerative medicine
”
p63 TAp63 ΔNp63α keratinocyte proliferation cornified cell envelope epidermal barrier Wnt signaling BMP signaling myoepithelial stem cells melanocyte stem cells mesenchymal stem cells hair growth nuclear envelope nucleolus nuclear bodies chromatin remodeling keratinocyte differentiation epigenetic machinery pharmaco-epigenomics Wnt BMP stem cells nucleus chromatin epigenetics
Studysummary This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.
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