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All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes

5 citations, February 2016 in “Genetic Testing and Molecular Biomarkers”

Hair loss is significantly linked to lower levels of certain genes in hair follicles.

research Keratin Formation in the Hair Follicle

34 citations, August 1966 in “Experimental cell research”

Keratin fibrils in hair form and stop growing at specific points in the follicle.

research Is There Any Relationship Between Decreased AgNOR Protein Synthesis and Human Hair Loss?

19 citations, July 2012 in “Biotechnic & Histochemistry”

Less AgNOR protein production is linked to hair loss.

research Finasteride-Related Leydig Cell Tumor: Report of a Case and Literature Review

5 citations, May 2012 in “Andrologia”

Finasteride use may be linked to rare testicular tumor, but more research needed.

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community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 50 upvotes 5 months ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community Does melatonin dissolve in isopropyl alcohol

in Technology 7 upvotes 2 years ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community Blaming Finasteride doesn't help you solve anything: dry eyes

in Finasteride/Dutasteride 52 upvotes 5 months ago

Finasteride is debated for causing dry eyes, with some users experiencing relief after stopping it, while others find no connection. Topical treatments like dutasteride and minoxidil are suggested as alternatives, with advice to consult medical professionals.

community VDPHL-01 is Overrated and Ridiculous. This is just Oral Minoxidil.

in Research/Science 22 upvotes 5 months ago

VDPHL-01 is essentially a slow-release oral minoxidil, which is already known to work for hair growth. The formulation includes other ingredients like Medrogestone, Valproic acid, Setipiprant, and Cetirizine, but their effectiveness and necessity are questioned.

community Breezula phase 3 results said to be released next month

in Product 26 upvotes 7 months ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

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