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All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes

5 citations, February 2016 in “Genetic Testing and Molecular Biomarkers”

Hair loss is significantly linked to lower levels of certain genes in hair follicles.

research Keratin Formation in the Hair Follicle

34 citations, August 1966 in “Experimental cell research”

Keratin fibrils in hair form and stop growing at specific points in the follicle.

research Is There Any Relationship Between Decreased AgNOR Protein Synthesis and Human Hair Loss?

19 citations, July 2012 in “Biotechnic & Histochemistry”

Less AgNOR protein production is linked to hair loss.

research Finasteride-Related Leydig Cell Tumor: Report of a Case and Literature Review

5 citations, May 2012 in “Andrologia”

Finasteride use may be linked to rare testicular tumor, but more research needed.

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community Does melatonin dissolve in isopropyl alcohol

in Technology 6 upvotes 1 year ago

The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

community Do hair follicles ever really "die"? Or does all your front, mid, and crown hair just become vellus?

in Chat 139 upvotes 3 months ago

Hair follicles don't truly die but become severely miniaturized. Treatments like finasteride, dutasteride, and minoxidil can help restore hair by providing nutrients and reducing harmful effects on hair roots.

community This Is A Minoxidillo. Could It Hold The Key To Solving Hair Loss?

in Satire 377 upvotes 1 year ago

The conversation is about different treatments for hair loss, including minoxidil, finasteride, RU58841, macroneedling, and pyrilutamice.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community 2.5 yrs progress: Min + dermaroll + niz

in Progress Pictures 76 upvotes 1 year ago

A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.

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