TLDR Hedgehog signaling is crucial for mammary gland development over hair follicles.
The document reviewed the roles of Hedgehog (Hh) and Gli proteins in the development of murine embryonic mammary glands, focusing on the Extratoes mutation, a functional null-mutation of the Gli3 gene. It proposed that the off-state of Hh signaling, mediated by the Gli3-repressor, was crucial for determining mammary gland fate over hair follicle fate in the trunk surface ectoderm.
72 citations,
November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
5 citations,
August 2013 in “InTech eBooks” KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.
62 citations,
November 2009 in “Aging Cell” Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.
479 citations,
January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.
