Hedgehog And Gli Signaling In Embryonic Mammary Gland Development

    May 2013 in “ Journal of mammary gland biology and neoplasia ”
    May Yin Lee, Li Sun, Jacqueline M. Veltmaat
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    TLDR Hedgehog signaling is crucial for mammary gland development over hair follicles.
    The document reviewed the roles of Hedgehog (Hh) and Gli proteins in the development of murine embryonic mammary glands, focusing on the Extratoes mutation, a functional null-mutation of the Gli3 gene. It proposed that the off-state of Hh signaling, mediated by the Gli3-repressor, was crucial for determining mammary gland fate over hair follicle fate in the trunk surface ectoderm.
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