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Glossary Chromatin Remodeling

restructuring of DNA-protein complexes to regulate gene expression

Chromatin remodeling refers to the dynamic modification of the structure of chromatin, which is the complex of DNA and proteins in the nucleus of a cell. This process involves the repositioning or restructuring of nucleosomes (the basic units of chromatin) to either expose or hide specific DNA regions, thereby regulating gene expression. For a layperson, it's like rearranging books on a shelf to make certain ones easier to read, while for a professional, it involves understanding the specific molecular mechanisms and enzymes, such as ATP-dependent chromatin remodelers, that facilitate these changes.

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research ATP-dependent chromatin remodeling during mammalian development

182 citations , August 2016 in “Development”

This review discusses the roles and mechanisms of chromatin remodelers and their subunits in mammalian development, but reports no new experimental results.

research p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis

166 citations , September 2011 in “The Journal of Cell Biology”

This study found that the p63 transcription factor plays a role in epidermal morphogenesis by regulating Satb1 expression, impacting chromatin architecture and gene expression in epidermal progenitor cells.

research Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression

85 citations , January 2018 in “Cell stem cell”

This study found that synchronized signals in the microenvironment regulate stem cell lineage choices in hair follicles by influencing chromatin dynamics during regeneration.

research Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation

13 citations , December 2017 in “Stem cells”

This study found that in mice, low-dose irradiation causes stem cells in hair follicles to undergo chromatin alterations, which may eventually lead to long-term functional loss in tissues or organs.

research The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity

January 2018 in “Stem cell biology and regenerative medicine”

This paper reviews the role of ATP-dependent chromatin remodeling complexes in epidermal homeostasis, hair regeneration, and skin repair, noting contributions to 3D-genomic organization and suppression of UV-induced hyper-proliferation, without presenting new results.

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