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GlossaryChromatin Remodeling

restructuring of DNA-protein complexes to regulate gene expression

Chromatin remodeling refers to the dynamic modification of the structure of chromatin, which is the complex of DNA and proteins in the nucleus of a cell. This process involves the repositioning or restructuring of nucleosomes (the basic units of chromatin) to either expose or hide specific DNA regions, thereby regulating gene expression. For a layperson, it's like rearranging books on a shelf to make certain ones easier to read, while for a professional, it involves understanding the specific molecular mechanisms and enzymes, such as ATP-dependent chromatin remodelers, that facilitate these changes.

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research ATP-Dependent Chromatin Remodeling During Mammalian Development

182 citations, August 2016 in “Development”

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

research Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression

85 citations, January 2018 in “Cell stem cell”

Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.

research Hair Follicle Stem Cell Fate Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation

13 citations, December 2017 in “Stem cells”

Low-dose radiation affects hair stem cell function and survival by changing their genetic material's structure.

research The Role of ATP-Dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity

January 2018 in “Stem cell biology and regenerative medicine”

ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.

research Tailored Chromatin Modulation to Promote Tissue Regeneration

10 citations, May 2019 in “Seminars in Cell & Developmental Biology”

Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.