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GlossaryHistone Modifications

chemical changes to histone proteins that regulate gene expression

Histone modifications refer to chemical changes made to histone proteins, which help package DNA in the cell nucleus. These modifications, such as methylation or acetylation, can influence gene expression by either tightening or loosening the DNA around histones, thereby controlling access to genetic information. This process is crucial for regulating various biological functions and can impact conditions like alopecia by affecting the genes involved in hair growth.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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research Epigenetic Regulation in Adult Stem Cells and Cancers

20 citations , January 2013 in “Cell & Bioscience”

Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.

research Epigenetic Control of Adult Stem Cell Function

179 citations , July 2016 in “Nature Reviews Molecular Cell Biology”

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

research Transcriptional Regulation of the Thymus Master Regulator Foxn1

6 citations , August 2022 in “Science immunology”

Foxn1 gene regulation is crucial for thymus development but not for hair growth.

research Epigenetics and Other Autoimmune Skin Diseases

2 citations , January 2015 in “Elsevier eBooks”

Epigenetic changes contribute to autoimmune skin diseases.

research Cell Fate Decisions: Emerging Roles for Metabolic Signals and Cell Morphology

100 citations , November 2017 in “EMBO Reports”

Metabolic signals and cell shape influence how cells develop and change.

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community So I just continue Finasteride for the rest of my life and I get to keep my hair?

in Finasteride/Dutasteride 157 upvotes 6 months ago

Finasteride can help maintain hair and slow hair loss, but its effectiveness varies by individual. Some may switch to dutasteride or add minoxidil for better results, though side effects are a concern.

community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 2 years ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.