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GlossaryHistone Modifications

chemical changes to histone proteins that regulate gene expression

Histone modifications refer to chemical changes made to histone proteins, which help package DNA in the cell nucleus. These modifications, such as methylation or acetylation, can influence gene expression by either tightening or loosening the DNA around histones, thereby controlling access to genetic information. This process is crucial for regulating various biological functions and can impact conditions like alopecia by affecting the genes involved in hair growth.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

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research Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

191 citations, September 2011 in “Cell stem cell”

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

research Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

48 citations, September 2011 in “British Journal of Dermatology”

Epigenetic changes in blood cells may contribute to alopecia areata.

research Novel Advances of Histone Modification in Inflammatory Skin Diseases and Related Treatment Methods

January 2024 in “Frontiers in immunology”

Histone modification is key in treating chronic inflammatory skin diseases.

research Epigenetic Control of Adult Stem Cell Function

179 citations, July 2016 in “Nature Reviews Molecular Cell Biology”

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations, November 2020 in “International Journal of Molecular Sciences”

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

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community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.