Epigenetics and Other Autoimmune Skin Diseases

    January 2015 in “ Elsevier eBooks ”
    Ming Zhao, Ruifang Wu, Qianjin Lu
    TLDR Epigenetic changes contribute to autoimmune skin diseases.
    Epigenetic mechanisms, such as DNA methylation, histone modifications, and microRNA, played a crucial role in gene expression regulation and were implicated in the development of various diseases, including autoimmune skin disorders. Dysregulation of these mechanisms, influenced by environmental, dietary, and mental factors, could lead to conditions like systemic lupus erythematosus, systemic scleroderma, and psoriasis. Although research on epigenetic changes in vitiligo, alopecia areata, dermatomyositis, and pemphigus vulgaris was still emerging, this review highlighted the importance of understanding these modifications to better comprehend and potentially treat these diseases.
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