TLDR Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.
This document reviews recent advances in understanding the inflammatory memory of epidermal stem cells, particularly those in hair follicles, which are crucial for wound healing, immune-related skin diseases, and skin cancer development. Inflammatory memory is a type of innate immune memory that is linked to epigenetic modifications or metabolic changes in cells, enabling them to respond more effectively to similar stimuli if encountered again. The review highlights that, like hematopoietic stem cells and fibroblasts, epidermal stem cells can also generate and maintain inflammatory memory. This discovery opens the door for future research aimed at developing targeted strategies to control the body's response to infections, injuries, and inflammatory skin conditions.
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105 citations
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October 2018 in “Nature” A small group of slow-growing cells causes basal cell carcinoma to return after treatment.
56 citations
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May 2017 in “Nature Cell Biology” Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
96 citations
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July 2014 in “Cold Spring Harbor Perspectives in Medicine” The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.
57 citations
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January 2014 in “Cold Spring Harbor Perspectives in Medicine” Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.
235 citations
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February 2011 in “Journal of Clinical Investigation” Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.
1039 citations
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February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
66 citations
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August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
