New Insights Into Inflammatory Memory of Epidermal Stem Cells

May 2023 in “ Frontiers in immunology ”

Dapeng Cheng, Seonjoo Lee, Shiqiang Yan, Linli Shi, Zhi Li, Xin Zhou, Xiaoning Bi

epidermal stem cells hair follicles wound healing immune-related skin diseases skin cancer inflammatory memory innate immune memory epigenetic modifications metabolic changes hematopoietic stem cells fibroblasts inflammatory skin conditions

TLDR Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

This document reviews recent advances in understanding the inflammatory memory of epidermal stem cells, particularly those in hair follicles, which are crucial for wound healing, immune-related skin diseases, and skin cancer development. Inflammatory memory is a type of innate immune memory that is linked to epigenetic modifications or metabolic changes in cells, enabling them to respond more effectively to similar stimuli if encountered again. The review highlights that, like hematopoietic stem cells and fibroblasts, epidermal stem cells can also generate and maintain inflammatory memory. This discovery opens the door for future research aimed at developing targeted strategies to control the body's response to infections, injuries, and inflammatory skin conditions.

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