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Glossary Inflammatory Mediators

substances released to initiate and regulate inflammation

Inflammatory mediators are substances released by immune cells and other tissues in response to injury or infection, which help to initiate and regulate the inflammatory response. These can include cytokines, prostaglandins, and histamines, among others, and they play crucial roles in signaling pathways that lead to symptoms like redness, swelling, and pain. Understanding these mediators is essential for developing treatments for conditions like alopecia, where inflammation can contribute to hair loss.

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Research

5 / 1000+ results

research Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways

9 citations , February 2025 in “Journal of Nanobiotechnology”

In this study, researchers found that using bioinspired nanovesicles derived from inflammation memory-activated epidermal stem cells effectively promoted healing in diabetic wounds by reprogramming neutrophils to an anti-inflammatory phenotype in both laboratory and animal models.

research New insights into inflammatory memory of epidermal stem cells

2 citations , May 2023 in “Frontiers in immunology”

This review highlights advances in understanding inflammatory memory in epidermal stem cells, focusing on their capacity to remember prior inflammatory responses and respond more quickly to future stimuli, potentially aiding strategies against skin-related diseases.

research Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

245 citations , October 2015 in “Nature medicine”

The research found that hair follicle–derived cytokines, particularly IL-15 and IL-7, regulate skin-resident memory T cells and their role in both immune homeostasis and lymphoma in the skin.

Neuroprotective and Immunomodulatory Effects of Human Hair Follicle Stem Cells on Streptozotocin-Induced Memory Impairment in Rats: Insights into Inflammation and Neurotrophic Mechanisms

research Neuroprotective and immunomodulatory effects of human hair follicle stem cells on streptozotocin-induced memory impairment in rats: insights into inflammation and neurotrophic mechanisms

May 2025

This study found that treating male rats with human hair follicle stem cells improved memory function impaired by streptozotocin and increased both neurotrophic and inflammatory markers, suggesting potential neuroprotective effects in this model.

research Skin in the Game: Stem Cells in Repair, Cancer, and Homeostasis

2 citations , March 2020 in “Cell”

This article reviews Elaine Fuchs’ groundbreaking discovery of adult skin stem cells' roles in homeostasis, wound repair, inflammation, and cancer, and reports no new results.

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Learn

3 / 801 results

learn Rosemary

herb and oil with stimulant, circulatory, anti-inflammatory and antioxidant properties

learn capsicum

Is capsicum safe for sensitive scalps or inflammatory hair loss? Capsicum may irritate sensitive scalps and worsen inflammatory hair loss.

learn Cetirizine

What makes cetirizine a unique anti-inflammatory option for your scalp? Laboratory work reports that cetirizine lowers PGD2 and other inflammatory mediators, which is why researchers have proposed it for the scalp. There is no approved topical product and the clinical evidence is one small unblinded pilot study in pattern hair loss, so scalp use is off-label and experimental.

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Community Join

5 / 306 results

community Severe dry eye: finasteride vs dutasteride

8 upvotes 5 years ago

Woman uses antiandrogens for hair thinning prevention, experiences severe dry eye with finasteride. Asks if dutasteride could be better despite potential for worse dry eye.

community People who have overcome the Dutasteride shed, could you please share your story ?

in Finasteride/Dutasteride 8 upvotes 4 weeks ago

People discussed their experiences with hair loss treatments, particularly dutasteride, finasteride, and minoxidil. Some users reported prolonged shedding with dutasteride, while others suggested adding topical anti-androgens like RU58841 to manage shedding.

community After quitting min and fin I asked AI on how fix the mess I am in and it says:

in Technology 1 year ago

Prolonged use of topical minoxidil and finasteride can lead to neuroendocrine and autonomic dysfunction, causing severe sensitivity and side effects. Recovery involves avoiding these treatments, supporting neurosteroid recovery, calming the sympathetic system, and rebuilding scalp health naturally.

community Reversed my hairloss without fin/min. 2023 December to 2025 April. IDK what happened.

565 upvotes 1 year ago

A user reversed hair loss using 10% sulfur soap, which reduced scalp inflammation and possibly demodex mites. The user did not use finasteride or minoxidil, suggesting inflammation may contribute to hair loss.

community People who continue to lose hair on fin/dut, Are you on Nicotine?

in Research/Science 81 upvotes 1 year ago

Nicotine use, especially from vaping, may worsen hair shedding and reduce the effectiveness of finasteride and dutasteride. Quitting nicotine seems to improve hair health.

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