Beta-1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis, and Migration of Their Progeny

    December 2013 in “ PLoS ONE ”
    Nancy Ernst, Arzu Yay, Tamás Bı́ró … Jennifer E. Kloepper
    Studysummary This study found that β1 integrin-mediated signaling is crucial for the survival, adhesion, and migration of epithelial progenitor cells in human scalp hair follicles, with varying responses observed among cell subpopulations.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.plos.org →
    Discuss this study in the Community →

    Research cited in this study 21

    1. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    2. Beta-1 Integrins with Individually Disrupted Cytoplasmic NPxY Motifs Are Embryonic Lethal but Partially Active in the Epidermis Journal of Investigative Dermatology · 2013
    3. Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering Journal of Dermatological Science · 2013
    4. The Role of Neprilysin in Regulating the Hair Cycle PLoS ONE · 2013
    5. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation, and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012
    6. Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin Journal of Allergy and Clinical Immunology · 2012
    7. Two- And Three-Dimensional Culture Of Keratinocyte Stem And Precursor Cells Derived From Primary Murine Epidermal Cultures Stem Cell Reviews and Reports · 2011
    8. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    9. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    10. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    11. Nonviral In Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells Stem Cells · 2009
    12. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    13. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    14. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    15. Hair Follicle Stem Cells: Walking the Maze European Journal of Cell Biology · 2007
    16. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    17. In Vitro Differences Between Keratinocyte Stem Cells and Transit-Amplifying Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2005
    18. Location and Phenotype of Human Adult Keratinocyte Stem Cells of the Skin Differentiation · 2004
    19. The Mouse Keratin 6 Isoforms Are Differentially Expressed in the Hair Follicle, Footpad, Tongue, and Activated Epidermis Differentiation · 1999
    20. Human Hair Growth In Vitro: A Model for the Study of Hair Follicle Biology Journal of Dermatological Science · 1994
    21. Epithelial Growth by Rat Vibrissae Follicles In Vitro Requires Mesenchymal Contact via Native Extracellular Matrix Journal of Investigative Dermatology · 1990