Neuregulin3 Alters Cell Fate in the Epidermis and Mammary Gland

September 2007 in “ BMC developmental biology ”

Heena Panchal, Olivia Wansbury, Suzanne Parry, Alan Ashworth, Beatrice A. Howard

Neuregulin3 NRG3 epidermis mammary gland epithelial proliferation ErbB receptors hyperproliferation sebaceous differentiation hair follicle structures epidermal proliferation sebaceous lineages hair lineage

TLDR Neuregulin3 affects cell development in the skin and mammary glands.

The study demonstrated that Neuregulin3 (NRG3) significantly influenced cell fate in the epidermis and mammary gland by regulating epithelial proliferation and development. Using transgenic mouse models, researchers observed that NRG3 altered the expression and activation of ErbB receptors, leading to phenotypic changes such as hyperproliferation, sebaceous differentiation, and abnormal hair follicle structures. The findings suggested that NRG3 promoted epidermal proliferation and differentiation into sebaceous lineages over hair lineage, highlighting its potential as a target for therapeutic strategies in related disorders.

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Neuregulin3 Alters Cell Fate in the Epidermis and Mammary Gland

Research cited in this study

research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells

research Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

research c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

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