TLDR Neuregulin3 affects cell development in the skin and mammary glands.
The study demonstrated that Neuregulin3 (NRG3) significantly influenced cell fate in the epidermis and mammary gland by regulating epithelial proliferation and development. Using transgenic mouse models, researchers observed that NRG3 altered the expression and activation of ErbB receptors, leading to phenotypic changes such as hyperproliferation, sebaceous differentiation, and abnormal hair follicle structures. The findings suggested that NRG3 promoted epidermal proliferation and differentiation into sebaceous lineages over hair lineage, highlighting its potential as a target for therapeutic strategies in related disorders.
384 citations,
June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
182 citations,
May 2003 in “Development” Myc activation reduces skin stem cells by affecting cell adhesion.
338 citations,
April 2001 in “Current Biology” c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
111 citations,
January 2007 in “Seminars in cell & developmental biology” Hair, teeth, and mammary glands develop similarly at first but use different genes later.
5 citations,
October 2014 in “Methods” The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.
5 citations,
February 2014 in “PloS one” Eyelid cells share signaling components but differ in pathway activity.
25 citations,
May 2013 in “Journal of mammary gland biology and neoplasia” Hedgehog signaling is crucial for mammary gland development over hair follicles.
52 citations,
October 2012 in “Journal of Dermatological Science” The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.
