The Pathogenesis of Primary Cicatricial Alopecias
October 2010
in “
The American Journal of Pathology
”
primary cicatricial alopecias hair follicle stem cells autoimmune disease immune attacks immune privilege collapse CD200 expression loss cell-mediated cytotoxicity proinflammatory responses apoptosis sebaceous gland dysfunction PPARγ deficiency PPAR-γ agonists environmental triggers genetic factors stress-induced inflammation PCAs PPAR gamma agonists
TLDR The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.
The document from November 2010 reviews the pathogenesis of primary cicatricial alopecias (PCAs), which are disorders causing permanent hair loss due to the destruction of hair follicle stem cells, often linked to autoimmune disease. It discusses the classification of PCAs based on inflammatory cells and the lack of understanding of the signaling pathways leading to immune attacks on hair follicle stem cells. The review emphasizes the need for further research to develop effective treatments and to understand the immunopathology of epithelial stem cells. It also explores the role of immune privilege collapse, CD200 expression loss, cell-mediated cytotoxicity, proinflammatory responses, apoptosis, sebaceous gland dysfunction, and PPARγ deficiency in PCA pathogenesis. The document suggests that PPAR-γ agonists may be promising for PCA therapy and highlights the potential role of environmental triggers, genetic factors, and stress-induced inflammation in PCA development. It concludes with a call for more attention to PCAs from researchers to improve diagnosis and treatment, and suggests a potential reclassification of PCAs based on molecular pathways.
