Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist

December 2009 in “ Archives of dermatology ”

Paradi Mirmirani, Pratima Karnik

lichen planopilaris primary cicatricial alopecia peroxisome proliferator-activated receptor γ agonist anti-inflammatory medications perifollicular erythema patchy alopecia diffuse thinning LPP PPARγ agonist

TLDR A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.

Lichen planopilaris (LPP), a type of primary cicatricial alopecia, caused permanent hair loss and was characterized by symptoms such as itching, burning, and pain of the scalp, along with patchy alopecia or diffuse thinning and perifollicular erythema and scale. Traditional treatments involved anti-inflammatory medications, which could alleviate symptoms but often did not halt the progression of hair loss.

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Research cited in this study

3 / 3 results

research Management of Primary Cicatricial Alopecias: Options for Treatment

98 citations, May 2008 in “British Journal of Dermatology”

There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.

research Maternal PPARγ Protects Nursing Neonates by Suppressing the Production of Inflammatory Milk

102 citations, July 2007 in “Genes & Development”

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

research The Medical Treatment of Cicatricial Alopecia

46 citations, March 2006 in “Seminars in Cutaneous Medicine and Surgery”

Current treatments for cicatricial alopecia can manage symptoms but don't stop hair loss or the disease.

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The individual has experienced a sore, stiff, and itchy scalp with hair loss for 4.5 years, and has noticed increased thinning and miniaturized hairs, especially at the temples. They have tried ketoconazole shampoo without success and are considering finasteride for treatment.

community The Worst Hair Loss Condition You (MAY) have: LPP

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Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.