Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist

    December 2009 in “ Archives of dermatology ”
    Paradi Mirmirani, Pratima Karnik
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    TLDR A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.
    Lichen planopilaris (LPP), a type of primary cicatricial alopecia, caused permanent hair loss and was characterized by symptoms such as itching, burning, and pain of the scalp, along with patchy alopecia or diffuse thinning and perifollicular erythema and scale. Traditional treatments involved anti-inflammatory medications, which could alleviate symptoms but often did not halt the progression of hair loss.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  57 upvotes 2 weeks ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  98 upvotes 1 month ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  80 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community Scalp is constantly uncomfortable and irritated with lots of hair loss

      in Chat  7 upvotes 1 year ago
      The individual has experienced a sore, stiff, and itchy scalp with hair loss for 4.5 years, and has noticed increased thinning and miniaturized hairs, especially at the temples. They have tried ketoconazole shampoo without success and are considering finasteride for treatment.

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