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GlossaryPPAR Agonists

activate nuclear receptors to regulate metabolism and inflammation

PPAR Agonists, or Peroxisome Proliferator-Activated Receptor Agonists, are compounds that activate PPARs, which are nuclear receptor proteins that regulate gene expression. These receptors play a crucial role in metabolism, inflammation, and cell differentiation, making PPAR agonists valuable in treating conditions like diabetes, obesity, and certain types of hair loss, such as alopecia.

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research Cicatricial Alopecia Research Foundation Meeting, May 2016: Progress Towards the Diagnosis, Treatment, and Cure of Primary Cicatricial Alopecias

22 citations, January 2018 in “Experimental Dermatology”

The meeting focused on understanding, diagnosing, and finding treatments for irreversible hair loss diseases.

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

54 citations, September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin A affects hair loss and immune response in alopecia areata.

Peroxisome Proliferator Activated Receptors Gamma Serum Levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case-Control Study

research Peroxisome Proliferator Activated Receptors Gamma Serum Levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case-Control Study

July 2022 in “Research Square (Research Square)”

Lower PPARγ levels and specific gene variations are linked to more severe Frontal Fibrosing Alopecia.

Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor Gamma Isoforms Are Differentially Expressed in Human Skin and Skin Appendages

research Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor Gamma Isoforms Are Differentially Expressed in Human Skin and Skin Appendages

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different types of PPARγ are found in varying amounts in human skin and its parts, which could affect how skin treatments work.

research The Pathogenesis of Primary Cicatricial Alopecias

150 citations, October 2010 in “The American Journal of Pathology”

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

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community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 4 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 828 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 1 month ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 1 month ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

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