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Glossary PPAR-alpha agonists

compounds that activate receptors to regulate lipid metabolism

PPAR-alpha agonists, also known as Peroxisome Proliferator-Activated Receptor Alpha agonists, are compounds that activate the PPAR-alpha receptor, a type of nuclear receptor involved in regulating lipid metabolism and inflammation. These agonists are often used in the treatment of conditions like hyperlipidemia and cardiovascular diseases because they help lower triglyceride levels and increase HDL (good cholesterol) levels in the blood.

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research Mechanism of PPARα agonist in alopecia areata

1 citations , January 2025 in “American Journal of Translational Research”

This study found that PPARα agonists provided protective effects in mouse models of alopecia areata by promoting early reversal of the condition and inhibiting T effector cell function, indicating potential therapeutic value for this inflammatory condition.

research Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?

60 citations , May 2015 in “Archives of dermatological research”

This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.

research PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

38 citations , January 2017 in “PPAR Research”

This review discusses the role of PPAR-γ in the pathogenesis of primary cicatricial alopecia, including its involvement in lichen planopilaris and treatment trials using PPAR-agonists, and reports no new clinical results.

research Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth

51 citations , September 2000 in “Acta dermato-venereologica”

This study found that PPAR alpha, -delta, and -gamma are expressed in human hair follicle cells, and clofibrate exhibited a beneficial effect on hair follicle survival in culture within a specific concentration range.

research The Pathogenesis of Primary Cicatricial Alopecias

150 citations , October 2010 in “The American Journal of Pathology”

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 3 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

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