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    Glossary PPAR-alpha agonists

    compounds that activate receptors to regulate lipid metabolism

    PPAR-alpha agonists, also known as Peroxisome Proliferator-Activated Receptor Alpha agonists, are compounds that activate the PPAR-alpha receptor, a type of nuclear receptor involved in regulating lipid metabolism and inflammation. These agonists are often used in the treatment of conditions like hyperlipidemia and cardiovascular diseases because they help lower triglyceride levels and increase HDL (good cholesterol) levels in the blood.

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    Research 30 of 938

    1. Mechanism of PPARα agonist in alopecia areata American Journal of Translational Research · 2025 · 1 citations
    2. Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics? Archives of dermatological research · 2015 · 60 citations
    3. PPAR-<i>γ</i> Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017 · 38 citations
    4. Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000 · 51 citations
    5. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018 · 80 citations
    6. PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology Experimental Dermatology · 2019 · 24 citations
    7. Hormone therapy in acne Indian Journal of Dermatology, Venereology and Leprology · 2013 · 24 citations
    8. What′s new in cicatricial alopecia? Indian Journal of Dermatology, Venereology and Leprology · 2013 · 16 citations
    9. Enhanced Insights into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies Dermatology and Therapy · 2024 · 1 citations
    10. Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress PLOS genetics · 2014 · 88 citations
    11. Lichen planopilaris and frontal fibrosing alopecia: review and update of diagnostic and therapeutic features 2022 · 13 citations
    12. Pathogenic Mechanisms and Mechanism‐Directed Therapies for Androgenetic Alopecia: Current Understanding and Future Directions Dermatologic Therapy · 2025
    13. Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling Burns & Trauma · 2025 · 5 citations
    14. Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An <i>in Silico</i> and <i>in Vitro</i> Study Environmental health perspectives · 2020 · 29 citations
    15. Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications Medical Review · 2024 · 6 citations
    16. How to diagnose a lipodystrophy syndrome Annales d'Endocrinologie · 2012 · 53 citations
    17. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    18. Medical therapy for frontal fibrosing alopecia: A review and clinical approach Journal of The American Academy of Dermatology · 2019 · 37 citations
    19. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    20. Optimal Management of Frontal Fibrosing Alopecia: A Practical Guide Clinical, Cosmetic and Investigational Dermatology · 2020 · 3 citations
    21. Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism bioRxiv (Cold Spring Harbor Laboratory) · 2026
    22. Treatment of frontal fibrosing alopecia and lichen planopilaris: a systematic review Journal of the European Academy of Dermatology and Venereology · 2013 · 117 citations
    23. Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment American Journal of Clinical Dermatology · 2019 · 61 citations
    24. Update on Frontal Fibrosing Alopecia Actas Dermo-Sifiliográficas · 2017 · 2 citations
    25. Cutaneous drug reactions Elsevier eBooks · 2010 · 1 citations
    26. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer Breast Cancer Research and Treatment · 2016 · 59 citations
    27. Antidiabetic Management Strategies for Treatment of Polycystic Ovarian Syndrome Journal of Neonatal Surgery · 2025
    28. Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis Dermatology and Therapy · 2021 · 78 citations
    29. Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway Inflammopharmacology · 2026
    30. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations