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PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

GMG-43AC may help reduce unwanted hair growth and treat certain hair loss conditions.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Foxn1 is important for fat development, metabolism, and wound healing in skin.

Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.

Syndecan-1 is essential for maintaining skin fat and preventing cold stress.

The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.

Medications for glucose metabolism and weight control, combined therapy options, and herbal medicines may help regulate menstrual cycle in adolescents with PCOS.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Finasteride harms Daphnia magna's reproduction, growth, and metabolism.

Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.

Early diagnosis and combination therapy, especially with finasteride and dutasteride, are key to managing Frontal Fibrosing Alopecia effectively.

Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

Five preservatives may disrupt hormone function and need more health and environmental risk assessment.

Central lipohypertrophy in HIV-infected women may lead to shorter eyelashes.

Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.

Bezafibrate treatment improved skin and spleen health in aging mice but didn't extend lifespan.

Lichen planopilaris is a rare, chronic condition causing hair loss, mainly in middle-aged women, and early treatment is important to prevent permanent baldness.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

Men with androgenetic alopecia have oilier and less hydrated scalps, especially in sensitive areas.

Plant-based products can improve hair and skin health without harmful side effects.

The document concludes that there are various treatments for different types of alopecia, but more research is needed for evidence-based treatments.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

The document concludes that there is a significant lack of reporting on the sex and age of cells in skin research, which could affect clinical trials and treatments.

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

Some plants with flavonoids may help treat hair loss and promote hair growth.