TLDR Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.
The study evaluated the interaction between the vitamin D receptor (VDR) and various coregulator binding motifs using two ligands: the natural ligand 1α,25(OH)2D3 and a synthetic agonist LG190178. It was found that VDR had a high affinity for specific LxxLL motifs in SRC1, SRC2, SRC3, and DRIP205, with similar binding patterns for both ligands, suggesting similar biological functions. The corepressor Hairless (Hr) bound VDR through a LxxLL motif, repressing transcription regardless of ligand presence. These findings could help predict tissue-specific VDR functions and aid in developing targeted vitamin D response modulators.
78 citations,
November 2005 in “Endocrinology” Hairless protein can block vitamin D activation in skin cells.
215 citations,
September 2003 in “Journal of Biological Chemistry” Vitamin D receptor and hairless protein are essential for hair growth.
15 citations,
March 2000 in “The journal of investigative dermatology/Journal of investigative dermatology” As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.
276 citations,
April 2003 in “Molecular endocrinology” Vitamin D is important for bones, hair, blood pressure, and breast development.
78 citations,
November 2005 in “Endocrinology” Hairless protein can block vitamin D activation in skin cells.
36 citations,
February 2007 in “Journal of biological chemistry/The Journal of biological chemistry” The vitamin D receptor can work without its usual activating molecule.
1308 citations,
March 1998 in “Journal of bone and mineral research” The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
