Suppression of Vitamin D Receptor and Induction of Retinoid X Receptor Alpha Expression During Squamous Differentiation of Cultured Keratinocytes

    March 2000 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Siegfried Segaert, Marjan Garmyn, Hugo Degreef, Roger Bouillon
    Studysummary This study found that vitamin D receptor expression is associated with proliferating keratinocytes, while retinoid X receptor α is linked to differentiating keratinocytes, suggesting differential targeting by vitamin D metabolites.
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    Research cited in this study 5

    1. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice Endocrinology · 1998
    2. The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed Journal of bone and mineral research · 1998
    3. Proliferation and Differentiation of Cultured Human Keratinocytes Is Modulated by 1,25-Dihydroxyvitamin D3 and Synthetic Vitamin D3 Analogues in a Cell Density-, Calcium-, and Serum-Dependent Manner Pharmacology & toxicology · 1997
    4. In Situ Detection of Retinoid-X Receptor Expression in Normal and Psoriatic Human Skin British journal of dermatology/British journal of dermatology, Supplement · 1995
    5. The Effect of 1,25-Dihydroxyvitamin D3 on the Growth and Differentiation of Cultured Human Outer Root Sheath Cells from Normal Subjects and Patients with Vitamin D-Dependent Rickets Type II with Alopecia Journal of Dermatological Science · 1991