TLDR Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.
The study investigated the effects of normalizing mineral ion levels through diet in vitamin D receptor (VDR)-ablated mice. It was found that this dietary intervention prevented secondary hyperparathyroidism, rickets, and osteomalacia by normalizing growth and serum ionized calcium levels. Despite these improvements, alopecia persisted in the VDR-ablated mice, indicating that the vitamin D receptor is essential for normal hair growth. This suggested that while mineral ion homeostasis could prevent certain conditions associated with vitamin D deficiency, it could not address hair loss, highlighting the specific role of the VDR in hair growth.
95 citations
,
July 2006 in “British Journal of Dermatology” Vitamin D receptors in hair follicles change with the hair cycle, affecting hair growth.
100 citations
,
October 1986 in “Clinical Endocrinology” Alopecia indicates more severe resistance to 1,25-dihydroxyvitamin D.
55 citations
,
May 1985 in “Archives of Dermatology” Calcitriol-resistant rickets is an inherited disorder that affects hair growth and causes hair loss.
70 citations
,
November 1984 in “Cell & tissue research/Cell and tissue research” Vitamin D3 affects cell differentiation in specific skin areas.
57 citations
,
April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin D receptor is crucial for starting hair growth after birth.
51 citations
,
January 2003 in “Hormone Research in Paediatrics” Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.
143 citations
,
May 2007 in “Proceedings of the National Academy of Sciences” Vitamin D receptor is crucial for normal hair growth and preventing hair loss.
1533 citations
,
October 2008 in “Endocrine reviews” Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
119 citations
,
October 1998 in “Endocrinology” Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.
