Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

The study investigated the effects of normalizing mineral ion levels through diet in vitamin D receptor (VDR)-ablated mice. It was found that this dietary intervention prevented secondary hyperparathyroidism, rickets, and osteomalacia by normalizing growth and serum ionized calcium levels. Despite these improvements, alopecia persisted in the VDR-ablated mice, indicating that the vitamin D receptor is essential for normal hair growth. This suggested that while mineral ion homeostasis could prevent certain conditions associated with vitamin D deficiency, it could not address hair loss, highlighting the specific role of the VDR in hair growth.